RELATIONSHIP BETWEEN CHOLESTEROL EFFLUX CAPACITY, APOLIPOPROTEIN A1 AND NONCALCIFIED CORONARY BURDEN IN PSORIASIS
نویسندگان
چکیده
منابع مشابه
Cholesterol efflux capacity in humans with psoriasis is inversely related to non-calcified burden of coronary atherosclerosis.
AIMS Cholesterol efflux capacity (CEC) was recently shown to predict future cardiovascular (CV) events. Psoriasis both increases CV risk and impairs CEC. However, whether having poor CEC is associated with coronary plaque burden is currently unknown. We aimed to assess the cross-sectional relationship between coronary plaque burden assessed by quantitative coronary computed tomography angiograp...
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Abstract Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the coronary artery disease (CAD).Small dense LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity...
متن کاملGlucocorticoid receptor regulates ATP-binding cassette transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages.
OBJECTIVE The ATP-binding cassette transporter-A1 (ABCA1) regulates cholesterol efflux from cells and is involved in high-density lipoprotein metabolism and atherogenesis. The objective of this study was to investigate the effect of dexamethasone (Dex) and other glucocorticoid receptor (GR) ligands on apolipoprotein AI-mediated cholesterol efflux from macrophages and ABCA1 expression in them. ...
متن کاملthe association between small dense low density lipoprotein,apolipoprotein b, apolipoprotein b/apolipoprotein a1 ratio and coronary artery stenosis
abstract background: recently, small dense low density lipoprotein (sdldl) has been highlighted as a new risk factor for the coronary artery disease (cad).small dense ldls are believed to be atherogenic since these particles are taken up more easily by arterial wall. they are readily oxidized and have reduced affinity for low density lipoprotein (ldl) receptor and increased affinity for arter...
متن کاملFamilial hypercholesterolaemia: cholesterol efflux and coronary disease
BACKGROUND Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. MATERIALS AND METHODS We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CH...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2020
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(20)32642-5